Insight into the mechanisms leading to the maintenance of masticatory muscles function in acute quadriplegic myopathy

ABSTRACT: Background: The aim of this study is to improve our understanding of the mechanisms underlying the sparing of masticatory muscles in ICU patients with acute quadriplegic myopathy (AQM) by using a unique porcine ICU model, i.e., 5-day longitudinal experiments where animals are sedated, mechanically ventilated and exposed to factors triggering AQM, such as muscle unloading, endotoxin-induced sepsis, and systemic exposure to CS and NMBA. Results: An increased expression was notably observed in atrogin-1, cathepsins, FoxO1a, runx1 and heat-shock proteins genes. A decreased expression in some sarcomeric proteins and myostatin genes was also noticed. Hence, modifications in heat-shock proteins and myostatin genes are in sharp contrast to alterations in the limb muscles and it is postulated that

ORGANISM(S): Sus scrofa

SUBMITTER: sudhakar aare 

PROVIDER: E-GEOD-24239 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress