The role of sepsis in the development of limb muscle weakness in a porcine ICU model

ABSTRACT: Background : The aim of this study is to improve our understanding of the mechanisms underlying the role of sepsis in the limb muscles of ICU patients with acute quadriplegic myopathy (AQM) by using a unique porcine ICU model, i.e., 5-day longitudinal experiments where animals are sedated, mechanically ventilated and exposed to factor triggering AQM that is endotoxin-induced sepsis. Results : An increased expression of genes involved in chemokine activity and transcriptional regulation. A decreased expression in genes regulating heat shock proteins, cytoskeletal & sarcomeric and oxidative stress response were also apparent. Therefore, it appears that sepsis has an additive deleterious role in acute quadriplegic myopathy. Sepsis-induced molecular mechanisms involving chemokine/innate immun

ORGANISM(S): Sus scrofa

SUBMITTER: sudhakar aare 

PROVIDER: E-GEOD-33037 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress