Murine skin gene expression analysis of skin-specific Scd1-deficient and control mice

ABSTRACT: To help elucidate the metabolic changes in the skin that contribute to the obesity resistance and skin pathology in mice lacking Scd1, we performed microarray analysis of skin gene expression in male skin Scd1 knockout (SKO) and Scd1 flox/flox control (Lox) mice fed a standard rodent diet. We identified an extraordinary number of differentially expressed genes that support the previously documented histological observations of sebocyte atrophy, inflammation and epidermal hyperplasia in SKO mice. Additionally, transcript levels were reduced in skin of SKO mice for genes involved in fatty acid synthesis, elongation and desaturation, which may be attributed to decreased abundance of key transcription factors including SREBP1c, ChREBP and LXR?. Conversely, genes involved in cholesterol synthes

ORGANISM(S): Mus musculus

SUBMITTER: Matthew Flowers 

PROVIDER: E-GEOD-24243 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress