The zinc cluster transcription factor Ahr1p directs Mcm1p regulation of Candida albicans adhesion

ABSTRACT: Biofilm development by Candida albicans requires cell adhesion for the initial establishment of the biofilm and the continued stability after hyphal development occurs; however, the regulation of the process has not been fully established. Using chromatin immunoprecipitation coupled to microarray analysis (ChIP-chip) we have characterized a regulon containing the Mcm1p factor that is required for the initial surface adhesion during biofilm formation. In the yeast Saccharomyces cerevisiae several Mcm1p regulons have been characterized in which regulatory specificity is achieved through co-factors binding a sequence adjacent to the Mcm1p-binding site. This new Mcm1p regulon in C. albicans also requires a co-factor, which we identify as the transcription factor Ahr1p. However, in contrast to

ORGANISM(S): Candida albicans

SUBMITTER: Adnane Sellam 

PROVIDER: E-GEOD-25174 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress