Transcription analysis of wild-type and chuR Bacteroides thetaiotaomicron genes in the mouse cecum

ABSTRACT: The large-scale application of genomic and metagenomic sequencing technologies has yielded a number of insights about the metabolic potential of symbiotic human gut microbes. Bacteria that colonize the mucosal layer that overlies the gut epithelium have access to highly-sulfated polysaccharides (i.e., mucin oligosaccharides and glycosaminoglycans), which they could potentially forage as nutrient sources. To be active, sulfatases must undergo a critical post-translational modification catalyzed in anaerobic bacteria by the AdoMet enzyme anSME (anaerobic Sulfatase-Maturating Enzyme). In the present study, we have tested the role of this pathway in the prominent gut symbiont Bacteroides thetaiotaomicron, which possesses more predicted sulfatases (28) than in the human genome and a single pred

ORGANISM(S): Bacteroides thetaiotaomicron

SUBMITTER: Eric Martens 

PROVIDER: E-GEOD-25415 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress