Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening

ABSTRACT: MicroRNAs (miRNAs) are small non-coding RNA molecules which function as negative gene regulators. The tissue expression profile of miRNAs shows great promise as a novel biomarker for diagnosis of cancer and other diseases. In addition, some recent reports have demonstrated that are present in human serum and plasma which could make them an ideal non-invasive biomarker for diagnosis of cancer. The aim of this study is to analyze the value/efficacy of the expression profile of plasma miRNAs in differentiating between patients with advanced adenomas and CRC and healthy individuals. The microRNA profiling study comprises serum plasmas from 20 Control, 21 colorectal cancer,20 advanced adenomas.The study also include some samples from patients after treatment.

ORGANISM(S): Homo sapiens

SUBMITTER: MarM-CM--a Dolores GirM-CM-!ldez 

PROVIDER: E-GEOD-25609 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study.

Giráldez María Dolores MD   Lozano Juan José JJ   Ramírez Georgina G   Hijona Elizabeth E   Bujanda Luis L   Castells Antoni A   Gironella Meritxell M  

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20121223 6

<h4>Background & aims</h4>Circulating microRNAs (miRNAs/miRs) might be used as biomarkers for the diagnosis of cancer and other diseases. Noninvasive approaches are needed to complement and improve upon current strategies for colorectal cancer (CRC) screening. We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), a  ...[more]

Similar Datasets

Unknown Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening
2013-01-11 | GSE25609 | GEO
Transcriptomics Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients
2010-05-16 | E-GEOD-14772 | biostudies-arrayexpress
Transcriptomics Quantitative RT-PCR profiling of miRNA expression of non-small cell lung cancer patients against healthy controls
2018-12-30 | E-MTAB-6304 | biostudies-arrayexpress
Transcriptomics RNA-Seq of tissue and plasma extracellular vesicles of breast cancer patients at the time of diagnosis and after the breast surgery
2022-10-24 | E-MTAB-12014 | biostudies-arrayexpress
Transcriptomics small RNA sequencing from plasma samples of SARS-CoV-2 infected patients
2022-04-03 | E-MTAB-10562 | biostudies-arrayexpress
Genomics Plasma circulating MiRNAs: a new potential biomarker for prostate cancer diagnosis.
| PRJNA484173 | ENA
Transcriptomics Small RNA-seq analysis of circulating miRNAs to identify phenotypic variability in Friedreich's ataxia patients
2017-10-18 | E-GEOD-105052 | biostudies-arrayexpress
Transcriptomics Analysis of circulating microRNAs in adrenocortical tumours
2013-11-19 | E-GEOD-49674 | biostudies-arrayexpress
Transcriptomics MicroRNAs as potential biomarkers for APE
2013-08-08 | E-GEOD-24149 | biostudies-arrayexpress
Transcriptomics RNA seq from plasma exosome before and after chemoradiotherapy for cervical cancer patients
2021-05-23 | E-MTAB-10215 | biostudies-arrayexpress