Analysis of Human Tendinopathy Gene Expression

ABSTRACT: Chronic tendon injuries, also known as tendinopathy, are common among professional and recreational athletes. These injuries result in a significant amount of morbidity and health care expenditure and yet little is known about the molecular mechanism leading to tendinopathy. We have used histological evaluation and molecular profiling to determine the gene expression changes in 23 human patients undergoing surgical procedures for the treatment of chronic tendinopathy. Diseased tendons have altered extracellular matrix, fiber disorientation, increased cellular content and vasculature and the absence of inflammatory cells. Global gene expression profiling identified 1783 transcripts with significant different expression patterns in the diseased tendons. Global pathway analysis further s

ORGANISM(S): Homo sapiens

SUBMITTER: Scott Jelinsky 

PROVIDER: E-GEOD-26051 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress