Histone acetylation and DNA demethylation of T-cells result in an anaplastic large cell lymphoma-like phenotype.

ABSTRACT: A characteristic feature of anaplastic large cell lymphoma (ALCL) is the significant reduction of the T-cell expression program despite its T-cell origin, a finding very similar to the loss of B-cell identity of classical Hodgkin lymphoma (cHL). Previously we demonstrated that epigenetic mechanisms are active in cHL to induce this peculiar phenotype. The results show that combined DNA demethylation and histone acetylation of T-cell lines induce an almost complete extinction of the T-cell phenotype, including the down-regulation of essential T-cell receptor signalling pathway genes such as CD3, LCK and ZAP70, as well as an up-regulation of ALCL-characteristic genes. In contrast, combined DNA demethylation and histone acetylation of ALCL cells is not able to reconstitute their T-cell phenot

ORGANISM(S): Homo sapiens

SUBMITTER: Maria Joosten 

PROVIDER: E-GEOD-26101 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress