Time course Healthy DMD myogenesis
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Ellen Sterrenburg
PROVIDER: E-GEOD-2693 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Gene expression profiling highlights defective myogenesis in DMD patients and a possible role for bone morphogenetic protein 4.
Sterrenburg Ellen E van der Wees Caroline G C CG White Stefan J SJ Turk Rolf R de Menezes Renée X RX van Ommen Gert-Jan B GJ den Dunnen Johan T JT 't Hoen Peter A C PA
Neurobiology of disease 20060506 1
Duchenne Muscular Dystrophy (DMD) is characterized by progressive muscle weakness and wasting. Despite the sustained presence of satellite cells in their skeletal muscles, muscle regeneration in DMD patients seems inefficient and unable to compensate for the continuous muscle fiber loss. To find a molecular explanation, we compared the gene expression profiles of myoblasts from healthy individuals and DMD patients during activation and differentiation in culture. DMD cultures showed significant ...[more]
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