Amorfrutins are selective PPARM-NM-3 agonists with potent antidiabetic properties

ABSTRACT: Faced by an alarming incidence of metabolic diseases including obesity and type 2 diabetes worldwide, there is an urgent need for effective strategies for preventing and treating these common diseases. The nuclear receptor PPARM-NM-3 (peroxisome proliferator-activated receptor gamma) plays a crucial role in metabolism. We isolated the amorfrutins from edible parts of the plants Glychyrrhiza foetida and Amorpha fruticosa, and identified these natural products as a new chemical class to treat insulin resistance and diabetes by selectively activating PPARM-NM-3. In contrast to existing synthetic PPARM-NM-3 drugs, the amorfrutins display unique properties by separating insulin sensitization from unwanted side effects. In obese mouse models, amorfrutin treatment significantly improved important

ORGANISM(S): Homo sapiens

SUBMITTER: Christopher Weidner 

PROVIDER: E-GEOD-28384 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress