Candida albicans Microarray studies: CAP2 (Wild type) vs. cap2D (Homozygous null mutant)
Ontology highlight
ABSTRACT:
ORGANISM(S): Candida albicans
SUBMITTER: Krishnamurthy Natarajan
PROVIDER: E-GEOD-28429 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans.
Singh Rana Pratap RP Prasad Himanshu K HK Sinha Ishani I Agarwal Neha N Natarajan Krishnamurthy K
The Journal of biological chemistry 20110518 28
Iron homeostasis is highly regulated in organisms across evolutionary time scale as iron is essential for various cellular processes. In a computational screen, we identified the Yap/bZIP domain family in Candida clade genomes. Cap2/Hap43 is essential for C. albicans growth under iron-deprivation conditions and for virulence in mouse. Cap2 has an amino-terminal bipartite domain comprising a fungal-specific Hap4-like domain and a bZIP domain. Our mutational analyses showed that both the bZIP and ...[more]
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