Differential miRNA expression in gingival epithelial cells infected with Porphyromonas gingivalis

ABSTRACT: Porphyromonas gingivalis is a pathogen in severe periodontal disease. Able to exploit an intracellular lifestyle within primary gingival epithelial cells (GECs), a reservoir of P. gingivalis can persist within the gingival epithelia. This process is facilitated by manipulation of the host cell signal transduction cascades which can impact cell cycle, cell death and cytokine responses. Using microarrays, we investigated the ability of P. gingivalis 33277 to regulate microRNA (miRNA) expression in GECs. One of several miRNAs differentially regulated by GECs in the presence of P. gingivalis was miR-203, which was upregulated 4-fold compared with uninfected controls. Differential regulation of miR-203 was confirmed by qRT-PCR. Putative targets of miR-203, suppressors of cytokine signaling

ORGANISM(S): Homo sapiens

SUBMITTER: Richard Lamont 

PROVIDER: E-GEOD-28635 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress