Protein phosphorylations, mediated by pro-inflammatory cytokines IL-32g and IL-17A/F

ABSTRACT: Global kinase activity induced by cytokines IL-32g and IL-17A/F were determined using peptide arrays representing phophorylation targets The objective of this study was to identify common and unique phosphorylation targets of pro-inflammatory cytokines IL-32 and IL-17. These cytokines are associated with the pathogenesis and severity of chronic inflammatory disorders, therefore signaling intermediates of these cytokines could be beneficial as alternate theraputic targets that may likely influence different inflammatory pathways. Phosphorylation of proteins is a critical mechanism in the regulation of cellular processes. This process is meticulously regulated by enzymes known as kinases, which are increasingly being identified as drug targets for a variety of diseases. In this study we inte

ORGANISM(S): Homo sapiens

SUBMITTER: Neeloffer Mookherjee 

PROVIDER: E-GEOD-28649 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress