Peripheral blood RNA expression profiling in illicit methcathinone users reveals effect on immune system

ABSTRACT: Methcathinone (ephedrone) is relatively easily accessible for abuse. Its users develop an extrapyramidal syndrome and it is not known if this is caused by methcathinone itself, by side-ingredients (manganese), or both. In the present study we aimed to clarify molecular mechanisms underlying this condition. We used microarrays to analyze whole genome gene expression patterns of peripheral blood from 20 methcathinone users and 20 matched controls. Gene expression profile data were analyzed by Bayesian modelling and functional annotation. Of 28,869 genes on the microarrays, 326 showed statistically significant differential expression with FDR adjusted p-values below 0.05. Quantitative RT-PCR confirmed differential expression for the most of the genes selected for validation. Functional annota

ORGANISM(S): Homo sapiens

SUBMITTER: Sulev Koks 

PROVIDER: E-GEOD-28686 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress