Expression profiling of peripheral blood of chronic HCV infection

ABSTRACT: In the present study, we studied chronic HCV patients who responded to IFN-based therapy as evidenced by absence of HCV RNA at the end of treatment, and focused on two issues that have not received much attention. Firstly, we evaluated whether specific genes or gene expression patterns in blood were able to distinguish responder patients with a viral relapse from responder patients who remained virus-negative after cessation of treatment. We found that chronic HCV patients who were sustained responders and relapsers to IFN-based therapy showed comparable baseline clinical parameters and immune composition in blood. However, at baseline, the gene expression profiles of a set of 18 genes predicted treatment outcome with an accuracy of 94%. Secondly, we examined whether patients with successf

ORGANISM(S): Homo sapiens

SUBMITTER: Andre Boonstra 

PROVIDER: E-GEOD-59312 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress