Global analysis of RNA secondary structure conservation between two metazoans

ABSTRACT: The secondary structure of RNA is necessary for its maturation, regulation, and processing. However, the global influence of RNA folding in eukaryotes is still unclear. Here, we identify evolutionarily conserved features of RNA secondary structure in metazoans by applying our high-throughput, sequencing-based, structure-mapping approach to Drosophila melanogaster and Caenorhabditis elegans. This analysis reveals key structural patterns across protein-coding transcripts that indicate RNA folding is influential to protein translation and microRNA-mediated targeting and/or regulation of mRNAs in animals. Additionally, we uncover a novel population of highly base-paired RNAs, many of which are likely functional, long, non-coding RNAs. Finally, we identify and characterize ~180 structural motif

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Fan Li 

PROVIDER: E-GEOD-29571 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress