SsDNA mapping in dmc1 strains
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Andreas Hochwagen
PROVIDER: E-GEOD-30071 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Protection of repetitive DNA borders from self-induced meiotic instability.
Vader Gerben G Blitzblau Hannah G HG Tame Mihoko A MA Falk Jill E JE Curtin Lisa L Hochwagen Andreas A
Nature 20110807 7362
DNA double strand breaks (DSBs) in repetitive sequences are a potent source of genomic instability, owing to the possibility of non-allelic homologous recombination (NAHR). Repetitive sequences are especially at risk during meiosis, when numerous programmed DSBs are introduced into the genome to initiate meiotic recombination. In the repetitive ribosomal DNA (rDNA) array of the budding yeast Saccharomyces cerevisiae, meiotic DSB formation is prevented in part through Sir2-dependent heterochromat ...[more]
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