Bacterial Adaptation Through Loss of Function
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ABSTRACT:
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655
SUBMITTER: Alison Hottes
PROVIDER: E-GEOD-30345 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Bacterial adaptation through loss of function.
Hottes Alison K AK Freddolino Peter L PL Khare Anupama A Donnell Zachary N ZN Liu Julia C JC Tavazoie Saeed S
PLoS genetics 20130711 7
The metabolic capabilities and regulatory networks of bacteria have been optimized by evolution in response to selective pressures present in each species' native ecological niche. In a new environment, however, the same bacteria may grow poorly due to regulatory constraints or biochemical deficiencies. Adaptation to such conditions can proceed through the acquisition of new cellular functionality due to gain of function mutations or via modulation of cellular networks. Using selection experimen ...[more]
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