Molecular characterisation of circulating tumor cells in human metastatic colorectal cancer

ABSTRACT: Metastatic colorectal cancer (mCRC) relies on the detachment of aggressive malignant cells from the primary tumor into the bloodstream, these Circulating Tumor Cells (CTC) being the principal source of the further metastasis. Here, we approached the massive molecular profiling of the CTC population isolated from mCRC patients. Clinically, the presence of CTC is associated with poor prognosis and there exists a clear necessity for more specific and efficient chemotherapies in the treatment of mCRC. Immunoisolation of CTC from these patients combined with a whole transcriptome amplification and hybridization onto gene expression arrays, lead us to specifically describe for the first time a CTC population with adhesive and migratory characteristics, in addition to a modulated expression of ge

ORGANISM(S): Homo sapiens

SUBMITTER: Miguel Abal 

PROVIDER: E-GEOD-31023 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress