Circadian temporal profiling of MMH-D3 hepatocytes

ABSTRACT: The circadian clock generates daily rhythms in mammalian liver processes, such as glucose and lipid homeostasis, xenobiotic metabolism, and regeneration. The mechanisms governing these rhythms are not well understood, particularly the distinct contributions of the cell-autonomous clock and central pacemaker to rhythmic liver physiology. Through microarray expression profiling in MMH-D3 hepatocytes, we identified over 1,000 transcripts that exhibit circadian oscillations, demonstrating that many rhythms can be driven by the cell-autonomous clock and that MMH-D3 is a valid circadian model system. The genes represented by these circadian transcripts displayed both co-phasic and anti-phasic organization within a protein-protein interaction network, suggesting the existence of competition for b

ORGANISM(S): Mus musculus

SUBMITTER: Susanna Wang 

PROVIDER: E-GEOD-31049 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress