Host influence on in vivo gene expression profiles of Plasmodium yoelii blood-stage malaria parasites

ABSTRACT: Microarray studies using synchronized Plasmodium falciparum parasites have revealed a ‘continuous cascade’ of gene expression. Reports vary regarding the stability in these transcriptional patterns in the presence of external stressors. Using Plasmodium yoelii 17X parasites replicating in vivo, we have examined differential gene expression in parasites isolated from individual mice, from independent infections, during ascending and peak parasitemia and in the presence and absence of host antibody responses. Across experimental conditions, transcription was surprisingly stable. Differential gene expression was greatest when comparing differences due to parasite load and/or host cell availability; however, even these changes were modest. Of genes that were differentially expressed, many

ORGANISM(S): Plasmodium yoelii

SUBMITTER: James Burns 

PROVIDER: E-GEOD-31274 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress