Human mesenchymal stem cells at 24 hours and 0.5% O2, gene expression and exon array, three independent biological replicates

ABSTRACT: Multipotent bone marrow-derived mesenchymal stem cells (MSCs) represent a promising cell source for autologous transplantation in many human diseases. To better realize their in vivo therapeutic potential, hypoxia preconditioning has become a novel strategy to improve the survival, migration, and angiogenic capability of MSCs. To elucidate the molecular mechanisms underlying the beneficial effect of hypoxia preconditioning on MSCs, we respectively used standard expression microarray and exon microarray to investigate the global profiling of gene expression and alternative splicing in hypoxia preconditioned-MSCs, and the detection sensitivity of differential gene expression using exon microarray and standard expression microarray was compared. A total of 414 genes were identified as signifi

ORGANISM(S): Homo sapiens

SUBMITTER: Hong Weiguo 

PROVIDER: E-GEOD-32006 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress