MpeR regulation in Neisseria gonorrhoeae (F19) through an iron-responsive mechanism

ABSTRACT: Previous studies have shown that the MpeR transcriptional regulator produced by Neisseria gonorrhoeae represses expression of mtrF, which encodes a putative inner membrane protein that works with the MtrC-MtrD-MtrE efflux pump to allow gonococci to resist high levels of multiple hydrophobic antimicrobials. Regulation of mpeR has been reported to occur by an iron-dependent mechanism involving Fur (Ferric uptake regulator). Collectively, these observations suggest the presence of an interconnected regulatory system in gonococci that modulates expression of drug efflux pump protein-encoding genes in an iron-responsive manner. Herein, we describe this connection and report that levels of gonococcal resistance to a substrate of the mtrCDE-encoded efflux pump can be modulated by MpeR and the

ORGANISM(S): Neisseria gonorrhoeae

SUBMITTER: Lydgia Jackson 

PROVIDER: E-GEOD-32717 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress