Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood

ABSTRACT: Inter-individual DNA methylation variations were frequently hypothesized to alter individual susceptibility to Type 2 Diabetes Mellitus (T2DM). Sequence-influenced methylations were described in T2DM-associated genomic regions, but evidence for direct, sequence-independent association with disease risk is missing. Here we explore disease-contributing DNA methylation through a stepwise study design: first, a pool-based, genome-scale screen among 1,169 case and control individuals revealed an excess of differentially methylated sites in genomic regions that were previously associated with T2DM through genetic studies. Next, in-depth analyses were performed at selected top-ranked regions. A CpG site in the first intron of the FTO gene showed small (3.35%) but significant (p=0.000021) hypometh

ORGANISM(S): Homo sapiens

SUBMITTER: Asaf Hellman 

PROVIDER: E-GEOD-33032 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress