Transcription profiling of rat spinal cord and oculomotor nucleus samples from animals aged 6, 18 and 30 months

ABSTRACT: Some of the most common neurodegenerative disorders have a strong association with aging. Curiously, these conditions tend to involve specific areas of the central and peripheral nervous system, at least initially. For example, amyotrophic lateral sclerosis preferentially targets spinal motor neurons and spares oculomotor neurons. This suggests that aging has divergent effects on brain stem and spinal cord, a factor that may explain differential susceptibility to certain neurodegenerative disorders. Therefore, for this study we asked whether aging induces a change in the evolution of the transcriptome of oculomotor nucleus (OMN) throughout the lifespan which would be different than that of the spinal cord aging. Age induced a transcriptome shift to a pattern consistent with inflammation/i

ORGANISM(S): Rattus norvegicus

SUBMITTER: Colleen McMullen 

PROVIDER: E-GEOD-3305 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress