Single cell fitness of B. subtilis correlates with the ability to adapt to various stresses.

ABSTRACT: How cells dynamically respond to fluctuating environmental conditions depends on the architecture and noise of the underlying genetic circuits. Most work characterizing stress pathways in the model bacterium Bacillus subtilis has been performed on bulk cultures using ensemble assays. However, investigating the single cell response to stress is important since noise might generate significant phenotypic heterogeneity. Here, we study a single stress response (glucose starvation) to allow comparison of both population- and single cell data. Using a top-down approach, we investigate the transcriptional dynamics of various stress-related genes of B. subtilis in response to glucose starvation. Our data reveal that most stress-induced pathways respond highly heterogeneously to glucose starvation.

ORGANISM(S): Bacillus subtilis

SUBMITTER: Imke de Jong 

PROVIDER: E-GEOD-33506 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress