Transcriptome analysis of Salmonella enterica serovar Typhimurium growth in physiological murine bile

ABSTRACT: Infection with Salmonella enterica serovar Typhi in humans causes the systemic, life-threatening disease typhoid fever. In the laboratory, typhoid fever can be modeled through the inoculation of susceptible mice with Salmonella enterica serovar Typhimurium. The ensuing disease is characterized by systemic dissemination and colonization of many organs, including the liver, spleen and gallbladder. Using this murine model, we previously characterized the interactions between Salmonella Typhimurium and host cells in the gallbladder and showed that this pathogen can successfully invade gallbladder epithelial cells and proliferate. Additionally, we showed that Salmonella Typhimurium can use bile phospholipids to grow at high rates. These abilities are likely important for quick colonization of t

ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium

SUBMITTER: L. Caetano Antunes 

PROVIDER: E-GEOD-33604 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress