Transcription profiling of Xenopus laevis gastrula ventral and dorsal halves at NF stages 10 and 11.5 injected with noggin and dkk-1 plasmid

ABSTRACT: Studies of the Xenopus organizer have laid the foundation for our understanding of the conserved signaling pathways that pattern vertebrate embryos during gastrulation. Here, we use this wealth of knowledge as leverage in the design and analysis of a genomic visualization of organizer-related gene transcription. Using ectopic expression of the two major activities of the organizer, BMP and Wnt inhibition, as well as endogenous tissues, we generate a focused set of samples that represent different aspects of organizer signaling. The genomic expression values of each sample are then measured with oligonucleotide arrays. From this data, genes regulated by organizer signaling are selected and then clustered by their patterns of regulation. A new GO biological process annotation of the Xen

ORGANISM(S): Xenopus laevis

SUBMITTER: Andrew Lee Hufton 

PROVIDER: E-GEOD-3368 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress