Mechanisms of adaptation to stress and control of virulence in Pseudomonas aeruginosa: the OxyR regulons

ABSTRACT: Oxidative stress caused by exposure to reactive oxygen species (ROS), is a major challenge for aerobic and especially anaerobic organisms. Bacteria coordinate the response to oxidative stress through the LysR-type transcriptional regulator (LTTR) OxyR. Extensive studies have focused on the classical Escherichia coli system to shed light on the mode of action of defensive weapons against oxidative stress. The underlying mechanism is mediated via the formation of redox-dependent disulfide bond between two conserved cysteines of OxyR, thus activating transcription of members of the OxyR regulon. However, only fragmentary information on the regulation and function of OxyR has been gleaned through genetic and biochemical analyses in the important opportunistic pathogen P. aeruginosa. In this re

ORGANISM(S): Pseudomonas aeruginosa PAO1

SUBMITTER: Pieter Monsieurs 

PROVIDER: E-GEOD-33871 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress