Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights

ABSTRACT: Transcription factors (TFs) play a central role in regulating gene expression by interacting with cis regulatory DNA elements associated with their target genes. Recent surveys have examined the DNA binding specificities of most Saccharomyces cerevisiae transcription factors but a comprehensive evaluation of their data has been lacking. Results: We analyzed in vitro and in vivo TF-DNA binding data reported in previous large-scale studies to generate a comprehensive, curated resource of DNA binding specificity data for all characterized S. cerevisiae transcription factors. Our collection comprises DNA binding site motifs and comprehensive in vitro DNA binding specificity data for all possible 8 bp sequences. Included in this database is DNA binding specificity data for 27 TFs independently

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Kevin Murphy 

PROVIDER: E-GEOD-34306 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress