Transcription profiling of Bos taurus mucosal derived ab and gd T cells during Salmonella enterica serovar typhimurium enterocolitis

ABSTRACT: gd T cells have an important yet incompletely defined role in inflammation associated with a variety of infectious and autoimmune conditions. To better understand the precise roles of gd T cells relative to ab T cells in a specific infection, we utilized Salmonella Enterica Serovar Typhimurium (S. typhimurium) infection in cattle as it is a leading cause of disease in cattle and closely approximates S. typhimurium-induced enterocolitis in humans. To best represent phenotype and gene expression changes occurring in the gut mucosa early in S. typhimurium infection, gd and ab T cells were collected directly from the mesenteric lymphatic ducts and analyzed by FACS or immediately sorted and processed for microarray analysis. Gene expression profiles were compared at intervals during infectio

ORGANISM(S): Bos taurus

SUBMITTER: Jodi Fern Hedges 

PROVIDER: E-GEOD-3439 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress