RNA-sequencing reveals allelic expression imbalance in the diploid pathogen Candida albicans

ABSTRACT: The diploid fungal pathogen Candida albicans is a highly heterozygous organism, with numerous non-synonymous substitutions often seen within two alleles. RNA-sequencing of the wild-type strain SC5314 has revealed 233 genes with significant levels of allelic expression imbalance. Overall percentage protein identity comparisons were significantly lower in these differentially expressed alleles. This suggests that two different, perhaps functionally divergent, proteins are being expressed at significantly different quantities by the two alleles of a single gene. Previously, gene expression levels have been correlated with structural factors such as GC content, ORF length and codon usage. Here, these factors were first correlated with overall gene expression data to decipher the relationship t

ORGANISM(S): Candida albicans

SUBMITTER: Sophie Shaw 

PROVIDER: E-GEOD-35233 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress