MiR-206 modulates the pathogenesis of muscular dystrophy of mdx mice

ABSTRACT: In response to skeletal muscle injury, adult myogenic stem cells, known as satellite cells, are activated and undergo proliferation and differentiation to regenerate new muscle fibers. The skeletal muscle-specific microRNA, miR-206, is up-regulated in satellite cells following muscle injury, but its role in muscle regeneration has not been defined. Here we show that skeletal muscle regeneration in response to cardiotoxin injury is impaired in mice lacking miR-206. Loss of miR-206 also accelerates and exacerbates the dystrophic phenotype of mdx mice, a model for Duchenne muscular dystrophy. MiR-206 promotes satellite cell differentiation and fusion to form multinucleated myofibers by suppressing a collection of negative regulators of myogenesis. Our findings reveal an essential role fo

ORGANISM(S): Mus musculus

SUBMITTER: Ning Liu 

PROVIDER: E-GEOD-36077 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress