Platypus fibroblast and ovary transcriptomes

ABSTRACT: As a result of sex chromosome differentiation from ancestral autosomes, male mammalian cells only contain one X chromosome. It has long been hypothesized that X-linked gene expression levels have become doubled in males to restore dosage balance between the X and autosomes, and that the resulting X overexpression in females then drove the evolution of X inactivation (XCI). However, this model has never been directly tested and patterns and mechanisms of dosage compensation across different mammals and birds generally remain little understood. We have traced the evolution of dosage compensation using extensive transcriptome data from males and females representing all major mammalian lineages and birds. Our analyses suggest that the X has become globally upregulated in marsupials but probab

ORGANISM(S): Ornithorhynchus anatinus

SUBMITTER: Philippe Julien 

PROVIDER: E-GEOD-36120 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress