Successful and failed human liver regeneration are characterized by the coordinated expression of distinct microRNAs

ABSTRACT: The liverM-bM-^@M-^Ys remarkable capacity to regenerate allows it to carry out vital life-supporting functions despite unrelenting pathogen and toxin-induced injury. Unchecked, this capability also leads to cirrhosis, a burgeoning global disease burden. Existing animal models only partially recapitulate human liver regeneration, which hitherto has not been systematically studied. We investigated human liver regeneration in a unique model of liver transplantation. Here we show coordinated changes in expression of microRNA (miRNA) during regeneration that drive proliferation, innate immunity and angiogenesis. Failed regeneration is associated with distinct miRNAs enforcing cell cycle inhibition and DNA methylation. The miRNA expression associated with successful or failed regeneration when r

ORGANISM(S): Homo sapiens

SUBMITTER: siamak salehi 

PROVIDER: E-GEOD-36146 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress