Discrete molecular states in the brain accompany changing responses to a vocal signal.

ABSTRACT: New experiences can trigger changes in gene expression in the brain. To understand this phenomenon better, we studied zebra finches hearing playbacks of birdsong. Earlier research had shown that initial playbacks of a novel song transiently increase the ZENK (ZIF-268, EGR1, NGFIA, KROX-24) mRNA in the auditory forebrain, but the response selectively habituates after repetition of the stimulus. Here, using DNA microarray analysis, we show that novel song exposure induces rapid changes in thousands of RNAs, with even more RNAs decreasing than increasing. Habituation training leads to the emer- gence of a different gene expression profile a day later, accompanied by loss of essentially all of the rapid "novel" molecular responses. The novel molecular profile is characterized by incr

ORGANISM(S): Taeniopygia guttata

SUBMITTER: Kirstin Replogle 

PROVIDER: E-GEOD-36269 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress