Differences in hepatic gene expression between lactating and non-lactating sows as assessed by genome-wide transcript profiling

ABSTRACT: Background: While the mechanisms underlying the lactation-induced adaptations of intermediary metabolism and immune response have been extensively studied in rodents and dairy cows, little is known in this regard in sows. Therefore, the present study aimed to explore the lactation-induced changes in hepatic gene expression in sows during lactation. Results: Using a porcine whole-genome microarray a total of 632 differentially expressed genes in the liver of lactating compared to non-lactating sows (each n = 10) could be identified. Enrichment analysis revealed that the differentially expressed genes were mainly involved in fatty acid metabolism, pyruvate metabolism, glutathione metabolism, glycine, serine and threonine metabolism, citrate cycle, glycerophospholipid metabolism, PPAR signali

ORGANISM(S): Sus scrofa

SUBMITTER: Robert Ringseis 

PROVIDER: E-GEOD-38357 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress