A microRNA network regulates expression and biosynthesis of CFTR and CFTR-M-NM-^TF508.

ABSTRACT: Production of functional proteins requires multiple steps including gene transcription and post-translational processing. MicroRNAs (miRNA) can regulate individual stages of these processes. Despite the importance of the cystic fibrosis transmembrane conductance regulator (CFTR) channel for epithelial anion transport, how its expression is regulated remains uncertain. We discovered that microRNA-138 regulates CFTR expression through its interactions with the transcriptional regulatory protein SIN3A. Treating airway epithelia with a miR-138 mimic increased CFTR mRNA and also enhanced CFTR abundance and transepithelial Cl- permeability independently of elevated mRNA levels. A miR-138 anti-miR had the opposite effects. Importantly, miR-138 altered the expression of many genes encoding p

ORGANISM(S): Homo sapiens

SUBMITTER: Shyam Ramachandran 

PROVIDER: E-GEOD-38956 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress