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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data for knockdown of H2ac in E2-treated MCF-7 cell lines

ABSTRACT: Estrogens(E2) are important steroid hormones that regulate differentiation, proliferation, and apoptosis in hormone-dependent breast cancer.In order to detect the E2-dependent transcription program associated with the observed cell cycle response, we analyzed the effect of H2ac knockdown on MCF-7 gene expression using microarray. Interestingly, we noticed that 51% of the E2-upregulated genes are down-regulated by depletion of H2ac. The data also show that H2ac regulated E2-dependent genes through E2-induction signaling pathway. MCF-7 cell line was transfected with scrambled or H2ac siRNA in the absence or persence of E2.

ORGANISM(S): Homo sapiens

SUBMITTER: CH Su

PROVIDER: E-GEOD-39786 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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