Hrp3 controls nucleosome positioning to suppress non-coding transcription in eu- and heterochromatin [MNase-Seq]

ABSTRACT: We report that the Schizosaccharomyces pombe CHD remodeler, Hrp3, is a global regulator that drives higher-order chromatin structure and genomic stability. The loss of Hrp3 resulted in nucleosome perturbation across the chromosome, and the production of antisense transcripts in the hrp3M-bM-^HM-^F cells emphasized the importance of nucleosome architecture for proper transcription Examination of nucleosome positions in wild-type and mutants using the MNase-seq method

ORGANISM(S): Schizosaccharomyces pombe

SUBMITTER: Yoonjung Choi 

PROVIDER: E-GEOD-40451 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress