Transcriptional perturbations caused by SV40 large T antigen and its fragments

ABSTRACT: The small genome of polyomaviruses encodes a limited number of proteins that are highly dependent on interactions with host cell proteins for efficient viral replication. The SV40 large T antigen (LT) contains several discrete functional domains that contribute to the viral life cycle, including the DNA binding and helicase domains. In addition, the LT the C-terminal region is required for lytic infection in certain restrictive cell types. To understand how LT affects the host cell to facilitate viral replication, we expressed full-length or functional domains of LT in cells and identified interacting cellular proteins and performed expression profiling. LT perturbed the expression of p53 target genes and subsets of cell-cycle dependent genes regulated by the DREAM and the B-Myb-MuvB com

ORGANISM(S): Homo sapiens

SUBMITTER: Megha Padi 

PROVIDER: E-GEOD-40567 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress