Proteomics

Dataset Information

155

Mouse retina proteomics - Integrative subcellular proteomic analysis allows accurate prediction of human disease causing genes


ABSTRACT: Proteomic experiments were performed on the outer segment (OS) and the remaining retina (RR). For the OS proteomics, three biological replicates were performed for mouse at the age of P15, which included 24, 26 and 26 retinas respectively. We also performed the OS proteomic experiment on 40 retinas from mice at age P13. For the RR proteomic experiments, two biological replicates were performed independently using 30 and 30 retinas respectively.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Retina, Eye Photoreceptor Cell

SUBMITTER: Li Zhao  

LAB HEAD: Rui Chen

PROVIDER: PXD003441 | Pride | 2016-02-26

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
P13_OS_run1_part1.msf Msf
P13_OS_run1_part1.raw Raw
P13_OS_run1_part2.msf Msf
P13_OS_run1_part2.raw Raw
P13_OS_run1_part3.msf Msf
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Publications

Integrative subcellular proteomic analysis allows accurate prediction of human disease-causing genes.

Zhao Li L   Chen Yiyun Y   Bajaj Amol Onkar AO   Eblimit Aiden A   Xu Mingchu M   Soens Zachry T ZT   Wang Feng F   Ge Zhongqi Z   Jung Sung Yun SY   He Feng F   Li Yumei Y   Wensel Theodore G TG   Qin Jun J   Chen Rui R  

Genome research 20160224 5


Proteomic profiling on subcellular fractions provides invaluable information regarding both protein abundance and subcellular localization. When integrated with other data sets, it can greatly enhance our ability to predict gene function genome-wide. In this study, we performed a comprehensive proteomic analysis on the light-sensing compartment of photoreceptors called the outer segment (OS). By comparing with the protein profile obtained from the retina tissue depleted of OS, an enrichment scor  ...[more]

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