Changes in gene expression in fruitfly ovaries in mutants affecting components of rasiRNA system

ABSTRACT: rasiRNA (rasiRNAs, repeat-associated short interfering RNAs) system is a mechanism of silencing of mobile element transpositions in germline of a number of species including Drosophila melanogaster. rasiRNA itself is a short RNAs which participate in transposon transcription repression and mRNA degradation. Defects in rasiRNA system lead to increased transposition rate and developmental abnormalities due to accumulation of double-strand DNA breaks in fruitfly testes and ovaries. A number of proteins participate in rasiRNA-mediated repression including SPN-E (homeless), PIWI and ARMI. Mutations in the genes of these proteins lead to significant mobile element mRNA accumulation. We performed microarray-based study of effects of spn-E mutation on expression in fruitfly ovaries - one of the

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Sergey Lavrov 

PROVIDER: E-GEOD-40768 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress