A compendium of RNA-binding motifs for analysis of gene regulation

ABSTRACT: RNA binding proteins are key regulators of gene expression, yet only a small fraction of these proteins has been functionally characterized. Here, we report the first large-scale analysis of the RNA motifs recognised by RNA binding proteins, encompassing 205 distinct proteins from 24 diverse eukaryotes. The sequence specificities of RBPs display deep evolutionary conservation, such that the recognition preferences for a large fraction of metazoan RNA binding proteins can be inferred from the sequences of their binding domains. The motifs we identify in vitro correlate well with in vivo RNA-binding data. Moreover, we can associate them with distinct functional roles in diverse types of post-transcriptional regulation, enabling new insights into the functions of RNA binding proteins in b

ORGANISM(S): synthetic construct

SUBMITTER: Debashish Ray 

PROVIDER: E-GEOD-41235 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress