Tranposable elements modulate human mRNAs and lncRNAs via specific RNA-protein interactions.

ABSTRACT: Transposable elements (TEs) have significantly influenced the evolution of transcriptional regulatory networks in the human genome. Post-transcriptional regulation of human genes by TE-derived sequences has been observed in specific contexts, but has yet to be systematically and comprehensively investigated. Here, studied a collection of CLIP-Seq (CrossLinked ImmunoPrecipitation) experiments mapping the RNA binding sites for a diverse set of 46 human proteins across 68 experiments to explore the role of TEs in post-transcriptional regulation genome-wide via RNA-protein interactions. We detected widespread interactions between RNA binding proteins (RBPs) and various families of TE-derived sequence in the CLIP-Seq data. Alignment coverage clustered on specific positions of the TE consensus s

ORGANISM(S): Homo sapiens

SUBMITTER: David Kelley 

PROVIDER: E-GEOD-61238 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress