Active STAT5 in CD8 T cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Nathalie AUPHAN-ANEZIN
PROVIDER: E-GEOD-41819 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Active STAT5 regulates T-bet and eomesodermin expression in CD8 T cells and imprints a T-bet-dependent Tc1 program with repressed IL-6/TGF-β1 signaling.
Grange Magali M Verdeil Grégory G Arnoux Fanny F Griffon Aurélien A Spicuglia Salvatore S Maurizio Julien J Buferne Michel M Schmitt-Verhulst Anne-Marie AM Auphan-Anezin Nathalie N
Journal of immunology (Baltimore, Md. : 1950) 20130904 7
In adoptive therapy, CD8 T cells expressing active STAT5 (STAT5CA) transcription factors were found to be superior to unmanipulated counterparts in long-term persistence, capacity to infiltrate autochthonous mouse melanomas, thrive in their microenvironment, and induce their regression. However, the molecular mechanisms sustaining these properties were undefined. In this study, we report that STAT5CA induced sustained expression of genes controlling tissue homing, cytolytic granule composition, ...[more]
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