Gene expression in Bach2-deficient and wildtype CD4 single-positive thymocytes from mixed chimeric animals

ABSTRACT: The role of FoxP3+ regulatory T (Treg) cells in the maintenance of immunological tolerance is well established. Recently, genome-wide association studies (GWAS) in humans have associated polymorphisms within the BACH2 locus encoding the transcription factor BTB and CNC homology 1, basic leucine zipper transcription factor 2 (Bach2) with diverse allergic and autoimmune diseases including asthma, multiple sclerosis, Crohn's disease, celiac disease, generalized vitiligo and type 1 diabetes. Common to these diseases is a failure to adequately maintain immunological tolerance. However, a role for Bach2 in this process has not been established. Here, by assessing the phenotype of mice in which the Bach2 gene is disrupted, we demonstrate a non-redundant role for Bach2 in the prevention of a spont

ORGANISM(S): Mus musculus

SUBMITTER: Francesco Marincola 

PROVIDER: E-GEOD-42598 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress