Regulating the angiogenic balance in tissues

ABSTRACT: A balance between angiogenesis inducers and inhibitors in the microenvironment controls the rate of new blood vessel formation. We hypothesized that fibroblasts, an important cellular constituent of the tissue stroma, secrete molecules that contribute to this balance. We further hypothesized that fibroblasts secrete molecules that promote angiogenesis when they are in a proliferative state and molecules that inhibit angiogenesis when they are not actively cycling (quiescent). Microarray analysis revealed that angiogenesis inducers and inhibitors are regulated as fibroblasts transition into a quiescent state and reenter the cell cycle in response to changes in serum. To assess whether changes in transcript levels result in changes in the levels of secreted proteins, we collected conditioned

ORGANISM(S): Homo sapiens

SUBMITTER: Eric Suh 

PROVIDER: E-GEOD-42681 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress