Chronic cocaine-regulated epigenome in mouse [ChIP-Seq]

ABSTRACT: Increasing evidence supports a role for altered gene expression in mediating the lasting effects of cocaine on the brain, and recent work has demonstrated the involvement of chromatin modifications in these alterations. However, all such studies to date have been restricted by their reliance on microarray technologies which have intrinsic limitations. Here, we used advanced sequencing methods, RNA-seq and ChIP-seq, to obtain an unprecedented view of cocaine-induced changes in gene expression and associated adaptations in numerous modes of chromatin regulation in the nucleus accumbens, a key brain reward region. We identify unique combinations of chromatin changes, or signatures, that accompany cocaine’s regulation of gene expression, including the dramatic involvement of pre-mRNA alternati

ORGANISM(S): Mus musculus

SUBMITTER: Li Shen 

PROVIDER: E-GEOD-42810 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress