TCR affinity-dependent functional inhibition via PD-1 and SHP-1 phosphatase

ABSTRACT: To investigate gene expression changes associated with stimulation of TCRs of different affinity, primary CD8 T cells were transduced with sequence optimized TCRs of various affinities and stimulated for 6h. Gene expression was measured at baseline (0h) and after 6h after stimulation with low dose NY-ESO-1 multimer

ORGANISM(S): Homo sapiens

SUBMITTER: Lukas Baitsch 

PROVIDER: E-GEOD-42922 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress